The Legacy of Adira Foundation.

A national foundation that invested in better lives for people living with neurodegenerative diseases. 2019 to 2022.

Circular infographic with an inner circle showing a group of peach-colored circles and the word 'Attra' in the center. Surrounding this are two rings with labels for Alzheimer's disease stages and locations, including 'Parkinson's,' 'Alzheimer's,' 'ALS,' and others, with the outer ring highlighted in shades of blue, beige, and red.

Our Origin Story

Greg Smiley, our founder, brought experience in both U.S. domestic health and global health systems. For nearly a decade within the UN system at UNAIDS, he drew inspiration from the monumental success of the Global Fund to Fight AIDS, TB, and Malaria, which secured enormous financial commitments and awarded grants to fight those diseases.

He secured over $4 million in seed financing, wrote a white paper on the concept, and commissioned George Washington University to make recommendations on the model.

Adira debuted inauspiciously in April 2020, just as COVID took over. Adira re-worked its initial round of grants, turning Round 1 into Emergency Fast Track Funding for 11 nonprofits.

Ultimately, Adira deployed three rounds of competitive grants, funded another five nonprofits directly with awards for highly inventive ideas, worked with another large donor to build "Adira in Miniature" across four rural states, and published research in Quality of Life metrics and similar issues.

In 2022, it attempted its most ambitious endeavor yet: building a Neurodegenerative Disease Congress of nearly 100 participants to design Round 4, with at least 51% of participants being patients and caregivers with lived experience.

Adira became another casualty of COVID pandemic. We were hamstrung by not being able to take in-person meetings, raise awareness, and to secure the funding we needed to match our pacing. The foundation deployed its resources to 26 nonprofits with urgency, but couldn’t keep our own fundraising move apace. The board decided to table Round 4, summarize all learnings to date by publishing a Blueprint for Action, wind down financially in the black, and sunset the organization. In a bittersweet blessing, Greg Smiley was able to pivot full-time to primary caregiving for his mother, living with terminal illness for the last 15 months of her life.

But our legacy lives on.

What Made Us Unique

Flowchart titled 'Adira’s diagonal approach to change: Both systems and people' illustrating steps in systemic change, including resources, impact, assembling, convening, setting priorities, reporting, learning, and evolving, with descriptive notes and examples.

Adira's approach blended the best of global health programs with a model that centered the people most impacted.


A timeline chart titled 'What We Did: A Timeline of Adira Foundation.' It details activities from 2020 to 2022, including listening, learning, acting phases, and specific projects, grants, and milestones for each year.

Adira's work unfolded across three years and three modes — listening to communities, learning from research, and acting through grants, before winding down ahead of its planned Round 4.


Why Neurodegenerative Diseases

The incidence, prevalence, costs, and burden of neurodegenerative diseases are growing rapidly. What's worse is that the people facing these scary, isolating, complex diagnoses are often the least equipped to handle them.

We focused principally, though not exclusively, on five disease communities: Alzheimer's disease and related dementias, ALS, Huntington's disease, multiple sclerosis, and Parkinson's disease. We believed these communities have far more in common than not, and we worked to galvanize support for co-created solutions to those common problems.

By 2030, the number of Americans living with these five diseases is expected to grow from 8 million to 11 million. That is a 38% increase.

Comparison of population growth from 2018 to 2030, showing an increase from 8 million in 2018 to 11 million in 2030 with different color-coded segments in horizontal bar graphs.

Working for the Common Good

Diagram showing common concerns and related diseases such as Alzheimer's, Parkinson's, Huntington's Disease, ALS, Multiple Sclerosis, in the context of neurodegenerative diseases with statistics and descriptions.
Three smiling women with painted hands showing pink, green, and blue paint. They are close together, smiling at the camera, with a background of an indoor setting.
Stack of informational flyers with a blue and red abstract design on a wooden surface.
A diverse group of people attending a meeting or conference in a modern, well-lit room with multiple large screens showing virtual participants.

Touring the Archive

To explore Adira's work:

  • Read further on this homepage to understand what made us unique

  • Visit Our Work to see the grant projects, the ND Congress, and the rural initiative

  • Browse Impact for annual reports, the Blueprint for Action, and the Quality of Life Metrics report

  • Dig into the Archive for the full library of materials, reports, and learnings

To learn more, please contact Greg Smiley.